WorkWize Wiki

Science

Fatigue is complex and driven by a multitude of processes in the human body, however, it is typically considered to be predominantly driven by the depletion of the catecholamine neurotransmitters. The catecholamine neurotransmitters are dopamine, noradrenalin and adrenalin. The body uses these neurotransmitters for motor function, concentration and motivation (via the dopamine reward system).

The nutrients used to produce the catecholamine neurotransmitters are tyrosine and phenylalanine. When the levels of these precursor nutrients runs low, your brain can’t make the neurotransmitters required to keep you alert and motivated and you feel depleted and fatigued. WorkWize is specially formulated to replenish these nutrients and to hydrate and energise your brain.

WorkWize fights fatigue with a combination of a Nootropic stack blended with electrolytes and energy creating vitamins and nutrients. The Nootropic blend of amino acids is designed to replenish the catecholamine neurotransmitters to fight fatigue at the bio-chemical source. A blend of chelated electrolytes rehydrates and replenishes what sweat takes out. A vitamin stack of C, B5, B6 and B12 promotes metabolic function and neurotransmitter production. And a synergistic blend of micronized creatine and acetyl carnitine promotes cellular energy production and utilisation through the ATP pathway.

The human brain is a complex organ that coordinates, monitors and actuates your entire body. In a typical human brain there are around 100 billion neurons. Each of these neurons needs specific nutrients to work effectively. WorkWize has been specially developed to replenish the nutrients your brain uses to maintain focus, motivate you to work, combat fatigue and keep you hydrated.
brain-neuro

Neurotransmission

The brain communicates to the body by sending signals through neurons in a process called neurotransmission. Neurotransmission relies on chemicals called neurotransmitters, which are created in the neuron from pre-cursor nutrients which must cross the blood brain barrier (BBB) and reside in the brain. The catecholamine neurotransmitters, dopamine and norephedrine keep you focused, alert and motivated while serotonin calms you down, regulates mood and promotes drowsiness.

image: Tyrosine Hydroxylase and Dopamine Synthesis.

Blood Brain Barrier (BBB)

The BBB is a selective semi-permeable membrane that is responsible for transporting nutrients from the blood to the brain. The precursor nutrients for the catecholamines and serotonin are Phenylalanine/Tyrosine (PHE/TYR) and Tryptophan (TRP) respectively, they are both amino acids found in most proteins. They share a competitive uptake mechanism in the BBB with several other amino acids including the BCAA’s. This competitive action means that if serum levels of TYR/PHE/BCAA decrease, then TRP transport and therefore seotonin production will increase (Choi, et al., 2013). As serotonin production increases, feelings of fatigue will arise.

image: Amino Acids in serum passing through cerebral capillary.

Precursor Nutrients

After physical or mental exercise, these precursor nutrients TRY/PHE/BCAA are consumed. The level of catecholamines drops and thus level of serotonin raises. This is a process known as central nervous system fatigue. Central fatigue as it is known, affects all physical and mental abilities, including strength, speed, reaction time, coordination, decision making, and balance. It worsens with time until the neurotransmitter level is restored. Research has shown that after an 8 hour shift of office work serum amino acid levels can drop up to 40% (Tanaka, et al., 2007). These levels can stay low even after a full nights sleep and adequate food (Tanaka, et al., 2007). This deficit likely compounds during shift work and extended hours. Leading to an increasing level of fatigue.

image: Change in serum amino acid level after 8 hours relative to baseline. The control group had 8 hours of relaxation while the work group had simulated mental workload (Tanaka, et al., 2007).

Amino-graph

Supplementation

Supplementation of the precursor amino acids has been shown to effectively increase serum levels which enables the brain to produce the vital neurotransmitters required to combat the onset of fatigue. Studies have shown that supplementation of both Tyrosine and the BCAA’s effectively regulate the change in neurotransmitter concentration characteristic of fatigue, due to sleep deprivation and stressors such as heat and cold (Mahoney, et al., 2007). Studies of Tyrosine supplementation have shown it can dramatically reduce the impacts of sleep deprivation on concentration and vigilance scales (Wiegmann & Shappell, 1993). Phenylalanine is converted by the body to Tyrosine, supplementation of Phenylalinine can allow for a longer lasting supply of Tyrosine in the body.

image: Error in a Compensatory Tracking Task during cadets subjected to sleep deprivation. This tracking task is similar to driving or monitoring processes onscreen (Wiegmann & Shappell, 1993).

sleep-graph

References

A M Williamson & Feyer, A.-M., 2000. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occupational Environmental Medicine, Volume 57, pp. 649-655.

Adibi, S., 1970. Leucine absorption rate and net movements of sodium and water in human jejunum. Journal of Applied Physiology, 28(6), pp. 753-757.

Åkerstedt, T., 2009. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. National Institute of Health, 4(2), pp. 257-271.

Ando, S. et al., 2001. Enhancement of Learning Capacity andCholinergic Synaptic Function by Carnitinein Aging Rats. Journal of Neuroscience Research, Volume 66, pp. 266-271.

Banderet, L. & Lieberman, H., 1988. Treatment with Tyrosine, a neurotransmitter precursor, reduces environmental stress in humans, Massachusetts: US Army Research Institute of Environmental Medicine.

Blomstran, E., 2006. A Role for Branched-Chain Amino Acids in Reducing Central Fatigue. The Journal of Nutrition, Volume 136, pp. 544-547.

Choi, S., DiSilvio, B., Fernstrom, M. & Fernstrom, J., 2013. Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. Amino Acids, Volume 45, pp. 1133-1142.

Cian, C. et al., 1999. Influences of variations in body hydration on cognitive function: Effect of hyperhydration, heat stress, and exercise-induced dehydration. Journal of Psychophysiology, 14(1), pp. 29-36.

Deijen, J. et al., 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin, 48(2), pp. 203-209.

Fernstrom, J. D., 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Volume 45.

House of Representatives, 2000. Beyond the Midnight Oil, Canberra: Commonwealth of Australia.

Kennedy, D. et al., 2010. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, Volume 211, pp. 55-68.

Lanni, C., Lenzken, S. & Pascale, A., 2008. Cognition enhancers between treating and doping the mind. Pharmacological Research, Volume 57, p. 196–213.

Mahoney, C. et al., 2007. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior, Volume 92, pp. 575-582.

Papadelis, C. et al., 2003. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain and Cognition, Volume 51, pp. 143-154.

Pasupathy, K. & Barker, L., 2011. Impact of fatigue on performance in registered nurses: data mining and implications for practice., s.l.: J Healthcare Quality.

Ricci, A. J., 2007. Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. JOEM, 49(1), pp. 1-9.

Seifert,, J., Harmon,, J. & DeClercq, P., 2006. Protein Added to a Sports Drink Improves Fluid Retention. International Journal of Sport Nutrition and Exercise Metabolism, Volume 16, pp. 420-429.

Smeland, O., Meisingset, T., Borges, K. & Sonnewald, U., 2012. Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61(1), pp. 100-107.

Tanaka, M., Mizuno, K. & Nozaki, S., 2007. Mental fatigue-induced decrease in levels of several plasma amino acids. Journal of Neural Transmission, Volume 114, pp. 555-561.

Vroman, R., 2011. Electrolyte Imbalances. EMS World, 40(2), pp. 40-43.

Watanabe, A., Kato, N. & Kato, T., 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, Volume 42, pp. 279-285.

Wiegmann, D. & Shappell, S., 1993. Behavioral Effects of Tyrosine during Sustained Wakefulness, Florida: Naval Aerospace Medical Research Laboratory.

Benefits

WorkWize is a revolution in workplace nutrition that combines modern research in neurochemistry and sports science to deliver a Nootropic electrolyte drink designed to enhance the safety and performance of workers in tough conditions. By replenishing several key nutrients in the brain WorkWize can offer many benefits.

reduced-mental-physical-fatigue

Reduced Mental & Physical Fatigue

Tyrosine and BCAA have been shown to combat fatigue by replenishing the bodies store of catecholamines, which are used for mental alertness and concentration. And by directly halting the mechanism of central fatigue by regulating the uptake of tryptophan which can be increased when BCAA and Tyrosine serum levels drop (Choi, et al., 2013), (Blomstran, 2006).

improved-hydration

Improved Hydration

WorkWize is a hypotonic electrolyte drink enhanced with amino acids. The addition of amino acids to hydration fluid has been shown to enhance fluid absorption and retention over that of an electrolyte mix or water alone (Adibi, 1970).

improved-mood

Improved Mood

Tyrosine and Phenylalanine are both precursor nutrients to several neurotransmitters which are responsible for motivation and mood regulation. Supplementing the bodies supplies means less mood degradation due to tough working conditions or excessive caffeine intake(Banderet & Lieberman, 1988).

increased-energy

Increased Energy

WorkWize contains creatine and carnitine. Both are used by the body to deliver energy into cells. Creatine is used by both the brain and skeletal muscles use to produce energy. It has been shown to increase power output in athletes and fuel the brain in those suffer from fatigue(Watanabe, et al., 2002). Carnitine has been shown to increase the availability of creatine and glucose use in the brain (Smeland, et al., 2012).

improved-alertness-focus

Improved Alertness & Focus

Tyrosine has been shown to increase cognition, alertness and memory in individuals suffering from sleep deprivation or under physical stress(Wiegmann & Shappell, 1993). Carnitine has been shown to increase acetylcholine, (a neurotransmitter) production in the brain which is used to concentrate and form logical thought(Ando, et al., 2001).

decreased-stress

Decreased Stress

Tyrosine, has been shown to decrease symptoms, adverse moods and performance impairments due to stressors such as sleep deprivation, stress, heat and cold(Deijen, et al., 1999). Additionally, B vitamins are vital for energy production and countless enzymatic processes in the human body. They help the human body deal with stress(Kennedy,et al., 2010).

References

A M Williamson & Feyer, A.-M., 2000. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occupational Environmental Medicine, Volume 57, pp. 649-655.

Adibi, S., 1970. Leucine absorption rate and net movements of sodium and water in human jejunum. Journal of Applied Physiology, 28(6), pp. 753-757.

Åkerstedt, T., 2009. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. National Institute of Health, 4(2), pp. 257-271.

Ando, S. et al., 2001. Enhancement of Learning Capacity andCholinergic Synaptic Function by Carnitinein Aging Rats. Journal of Neuroscience Research, Volume 66, pp. 266-271.

Banderet, L. & Lieberman, H., 1988. Treatment with Tyrosine, a neurotransmitter precursor, reduces environmental stress in humans, Massachusetts: US Army Research Institute of Environmental Medicine.

Blomstran, E., 2006. A Role for Branched-Chain Amino Acids in Reducing Central Fatigue. The Journal of Nutrition, Volume 136, pp. 544-547.

Choi, S., DiSilvio, B., Fernstrom, M. & Fernstrom, J., 2013. Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. Amino Acids, Volume 45, pp. 1133-1142.

Cian, C. et al., 1999. Influences of variations in body hydration on cognitive function: Effect of hyperhydration, heat stress, and exercise-induced dehydration. Journal of Psychophysiology, 14(1), pp. 29-36.

Deijen, J. et al., 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin, 48(2), pp. 203-209.

Fernstrom, J. D., 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Volume 45.

House of Representatives, 2000. Beyond the Midnight Oil, Canberra: Commonwealth of Australia.

Kennedy, D. et al., 2010. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, Volume 211, pp. 55-68.

Lanni, C., Lenzken, S. & Pascale, A., 2008. Cognition enhancers between treating and doping the mind. Pharmacological Research, Volume 57, p. 196–213.

Mahoney, C. et al., 2007. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior, Volume 92, pp. 575-582.

Papadelis, C. et al., 2003. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain and Cognition, Volume 51, pp. 143-154.

Pasupathy, K. & Barker, L., 2011. Impact of fatigue on performance in registered nurses: data mining and implications for practice., s.l.: J Healthcare Quality.

Ricci, A. J., 2007. Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. JOEM, 49(1), pp. 1-9.

Seifert,, J., Harmon,, J. & DeClercq, P., 2006. Protein Added to a Sports Drink Improves Fluid Retention. International Journal of Sport Nutrition and Exercise Metabolism, Volume 16, pp. 420-429.

Smeland, O., Meisingset, T., Borges, K. & Sonnewald, U., 2012. Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61(1), pp. 100-107.

Tanaka, M., Mizuno, K. & Nozaki, S., 2007. Mental fatigue-induced decrease in levels of several plasma amino acids. Journal of Neural Transmission, Volume 114, pp. 555-561.

Vroman, R., 2011. Electrolyte Imbalances. EMS World, 40(2), pp. 40-43.

Watanabe, A., Kato, N. & Kato, T., 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, Volume 42, pp. 279-285.

Wiegmann, D. & Shappell, S., 1993. Behavioral Effects of Tyrosine during Sustained Wakefulness, Florida: Naval Aerospace Medical Research Laboratory.

Ingredients

WorkWize is a premium blend of amino acids, vitamins, electrolytes and nutrients specifically formulated to help you achieve optimal performance during a busy workday. WorkWize is sugar free and coloured and flavoured with only natural fruit extracts and organic stevia.
workwize-ingredients-combined
amino-acids_L-tyrosine-workwize

Amino Acids

WorkWize contains; Tyrosine, Phenylalanine, Glycine and the Branched Chain Amino Acids (BCAA’s)(Leucine, Isoleucine and Valine). Tyrosine and Phenylaniline are converted to Catecholamines which keep the brain motivated, alert and active. The BCAA’s are used in energy production and supplementation can reduce fatigue. Glycine is utilised by the body in a multitude of functions. Consumption can assist brain health and help mitigate fatigue.

electrolytes_kaliumcitrat-workwize

Electrolytes

WorkWize contains all the major electrolytes needed by the human body; Sodium, Potassium, Chloride, Magnesium and Calcium, all in chelated form for optimal bio availability. The human body requires the presence of electrolytes in its serum and cellular fluids to enable signal transduction, to regulate osmotic gradients and for enzymatic reactions. Electrolytes are lost in sweat and need to be replenished.

vitamins_ascorbic_acid-workwize

Vitamins

The vitamin formulation in WorkWize has been designed to replenish the supply of vitamins used by the brain for cognitive function. WorkWize contains Vitamins C, B5, B6 and B12, all essential for countless enzymatic reactions, immune function, energy generation and neurotransmitter production. They are consumed by the body and need constant replenishment.

nutrients_creatine-neutral

Nutrients

WorkWize contains the vital nutrients Creatine and Carnitine to facilitate energy production. Creatine is an endogenous molecule vital to energy production in the human body by recycling cellular adenosine triphosphate (ATP). Carnitine is another endogenous nutrient that is linked to the conversion of fatty acids to energy by mitochondria.

References

A M Williamson & Feyer, A.-M., 2000. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occupational Environmental Medicine, Volume 57, pp. 649-655.

Adibi, S., 1970. Leucine absorption rate and net movements of sodium and water in human jejunum. Journal of Applied Physiology, 28(6), pp. 753-757.

Åkerstedt, T., 2009. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. National Institute of Health, 4(2), pp. 257-271.

Ando, S. et al., 2001. Enhancement of Learning Capacity andCholinergic Synaptic Function by Carnitinein Aging Rats. Journal of Neuroscience Research, Volume 66, pp. 266-271.

Banderet, L. & Lieberman, H., 1988. Treatment with Tyrosine, a neurotransmitter precursor, reduces environmental stress in humans, Massachusetts: US Army Research Institute of Environmental Medicine.

Blomstran, E., 2006. A Role for Branched-Chain Amino Acids in Reducing Central Fatigue. The Journal of Nutrition, Volume 136, pp. 544-547.

Choi, S., DiSilvio, B., Fernstrom, M. & Fernstrom, J., 2013. Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. Amino Acids, Volume 45, pp. 1133-1142.

Cian, C. et al., 1999. Influences of variations in body hydration on cognitive function: Effect of hyperhydration, heat stress, and exercise-induced dehydration. Journal of Psychophysiology, 14(1), pp. 29-36.

Deijen, J. et al., 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin, 48(2), pp. 203-209.

Fernstrom, J. D., 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Volume 45.

House of Representatives, 2000. Beyond the Midnight Oil, Canberra: Commonwealth of Australia.

Kennedy, D. et al., 2010. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, Volume 211, pp. 55-68.

Lanni, C., Lenzken, S. & Pascale, A., 2008. Cognition enhancers between treating and doping the mind. Pharmacological Research, Volume 57, p. 196–213.

Mahoney, C. et al., 2007. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior, Volume 92, pp. 575-582.

Papadelis, C. et al., 2003. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain and Cognition, Volume 51, pp. 143-154.

Pasupathy, K. & Barker, L., 2011. Impact of fatigue on performance in registered nurses: data mining and implications for practice., s.l.: J Healthcare Quality.

Ricci, A. J., 2007. Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. JOEM, 49(1), pp. 1-9.

Seifert,, J., Harmon,, J. & DeClercq, P., 2006. Protein Added to a Sports Drink Improves Fluid Retention. International Journal of Sport Nutrition and Exercise Metabolism, Volume 16, pp. 420-429.

Smeland, O., Meisingset, T., Borges, K. & Sonnewald, U., 2012. Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61(1), pp. 100-107.

Tanaka, M., Mizuno, K. & Nozaki, S., 2007. Mental fatigue-induced decrease in levels of several plasma amino acids. Journal of Neural Transmission, Volume 114, pp. 555-561.

Vroman, R., 2011. Electrolyte Imbalances. EMS World, 40(2), pp. 40-43.

Watanabe, A., Kato, N. & Kato, T., 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, Volume 42, pp. 279-285.

Wiegmann, D. & Shappell, S., 1993. Behavioral Effects of Tyrosine during Sustained Wakefulness, Florida: Naval Aerospace Medical Research Laboratory.