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SCIENCE
Fatigue is complex and driven by a multitude of processes in the human body, however, it is typically considered to be predominantly driven by the depletion of the catecholamine neurotransmitters. The catecholamine neurotransmitters are dopamine, noradrenalin and adrenalin. The body uses these neurotransmitters for motor function, concentration and motivation (via the dopamine reward system).
The nutrients used to produce the catecholamine neurotransmitters are tyrosine and phenylalanine. When the levels of these precursor nutrients runs low, your brain can’t make the neurotransmitters required to keep you alert and motivated and you feel depleted and fatigued. WorkWize is specially formulated to replenish these nutrients and to hydrate and energise your brain.
WorkWize fights fatigue with a combination of a Nootropic stack blended with electrolytes and energy creating vitamins and nutrients. The Nootropic blend of amino acids is designed to replenish the catecholamine neurotransmitters to fight fatigue at the bio-chemical source. A blend of chelated electrolytes rehydrates and replenishes what sweat takes out. A vitamin stack of C, B5, B6 and B12 promotes metabolic function and neurotransmitter production. And a synergistic blend of micronized creatine and acetyl carnitine promotes cellular energy production and utilisation through the ATP pathway.

Neurotransmission

Blood Brain Barrier (BBB)

Precursor Nutrients
Supplementation
A M Williamson & Feyer, A.-M., 2000. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occupational Environmental Medicine, Volume 57, pp. 649-655.
Adibi, S., 1970. Leucine absorption rate and net movements of sodium and water in human jejunum. Journal of Applied Physiology, 28(6), pp. 753-757.
Åkerstedt, T., 2009. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. National Institute of Health, 4(2), pp. 257-271.
Ando, S. et al., 2001. Enhancement of Learning Capacity andCholinergic Synaptic Function by Carnitinein Aging Rats. Journal of Neuroscience Research, Volume 66, pp. 266-271.
Banderet, L. & Lieberman, H., 1988. Treatment with Tyrosine, a neurotransmitter precursor, reduces environmental stress in humans, Massachusetts: US Army Research Institute of Environmental Medicine.
Blomstran, E., 2006. A Role for Branched-Chain Amino Acids in Reducing Central Fatigue. The Journal of Nutrition, Volume 136, pp. 544-547.
Choi, S., DiSilvio, B., Fernstrom, M. & Fernstrom, J., 2013. Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. Amino Acids, Volume 45, pp. 1133-1142.
Cian, C. et al., 1999. Influences of variations in body hydration on cognitive function: Effect of hyperhydration, heat stress, and exercise-induced dehydration. Journal of Psychophysiology, 14(1), pp. 29-36.
Deijen, J. et al., 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin, 48(2), pp. 203-209.
Fernstrom, J. D., 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Volume 45.
House of Representatives, 2000. Beyond the Midnight Oil, Canberra: Commonwealth of Australia.
Kennedy, D. et al., 2010. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, Volume 211, pp. 55-68.
Lanni, C., Lenzken, S. & Pascale, A., 2008. Cognition enhancers between treating and doping the mind. Pharmacological Research, Volume 57, p. 196–213.
Mahoney, C. et al., 2007. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior, Volume 92, pp. 575-582.
Papadelis, C. et al., 2003. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain and Cognition, Volume 51, pp. 143-154.
Pasupathy, K. & Barker, L., 2011. Impact of fatigue on performance in registered nurses: data mining and implications for practice., s.l.: J Healthcare Quality.
Ricci, A. J., 2007. Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. JOEM, 49(1), pp. 1-9.
Seifert,, J., Harmon,, J. & DeClercq, P., 2006. Protein Added to a Sports Drink Improves Fluid Retention. International Journal of Sport Nutrition and Exercise Metabolism, Volume 16, pp. 420-429.
Smeland, O., Meisingset, T., Borges, K. & Sonnewald, U., 2012. Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61(1), pp. 100-107.
Tanaka, M., Mizuno, K. & Nozaki, S., 2007. Mental fatigue-induced decrease in levels of several plasma amino acids. Journal of Neural Transmission, Volume 114, pp. 555-561.
Vroman, R., 2011. Electrolyte Imbalances. EMS World, 40(2), pp. 40-43.
Watanabe, A., Kato, N. & Kato, T., 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, Volume 42, pp. 279-285.
Wiegmann, D. & Shappell, S., 1993. Behavioral Effects of Tyrosine during Sustained Wakefulness, Florida: Naval Aerospace Medical Research Laboratory.
BENEFITS


Reduced mental & physical fatigue

Improved Hydration

Improved Mood

Increased Energy

Improved Alertness & Focus

Decreased Stress
A M Williamson & Feyer, A.-M., 2000. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occupational Environmental Medicine, Volume 57, pp. 649-655.
Adibi, S., 1970. Leucine absorption rate and net movements of sodium and water in human jejunum. Journal of Applied Physiology, 28(6), pp. 753-757.
Åkerstedt, T., 2009. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. National Institute of Health, 4(2), pp. 257-271.
Ando, S. et al., 2001. Enhancement of Learning Capacity andCholinergic Synaptic Function by Carnitinein Aging Rats. Journal of Neuroscience Research, Volume 66, pp. 266-271.
Banderet, L. & Lieberman, H., 1988. Treatment with Tyrosine, a neurotransmitter precursor, reduces environmental stress in humans, Massachusetts: US Army Research Institute of Environmental Medicine.
Blomstran, E., 2006. A Role for Branched-Chain Amino Acids in Reducing Central Fatigue. The Journal of Nutrition, Volume 136, pp. 544-547.
Choi, S., DiSilvio, B., Fernstrom, M. & Fernstrom, J., 2013. Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. Amino Acids, Volume 45, pp. 1133-1142.
Cian, C. et al., 1999. Influences of variations in body hydration on cognitive function: Effect of hyperhydration, heat stress, and exercise-induced dehydration. Journal of Psychophysiology, 14(1), pp. 29-36.
Deijen, J. et al., 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin, 48(2), pp. 203-209.
Fernstrom, J. D., 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Volume 45.
House of Representatives, 2000. Beyond the Midnight Oil, Canberra: Commonwealth of Australia.
Kennedy, D. et al., 2010. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, Volume 211, pp. 55-68.
Lanni, C., Lenzken, S. & Pascale, A., 2008. Cognition enhancers between treating and doping the mind. Pharmacological Research, Volume 57, p. 196–213.
Mahoney, C. et al., 2007. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior, Volume 92, pp. 575-582.
Papadelis, C. et al., 2003. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain and Cognition, Volume 51, pp. 143-154.
Pasupathy, K. & Barker, L., 2011. Impact of fatigue on performance in registered nurses: data mining and implications for practice., s.l.: J Healthcare Quality.
Ricci, A. J., 2007. Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. JOEM, 49(1), pp. 1-9.
Seifert,, J., Harmon,, J. & DeClercq, P., 2006. Protein Added to a Sports Drink Improves Fluid Retention. International Journal of Sport Nutrition and Exercise Metabolism, Volume 16, pp. 420-429.
Smeland, O., Meisingset, T., Borges, K. & Sonnewald, U., 2012. Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61(1), pp. 100-107.
Tanaka, M., Mizuno, K. & Nozaki, S., 2007. Mental fatigue-induced decrease in levels of several plasma amino acids. Journal of Neural Transmission, Volume 114, pp. 555-561.
Vroman, R., 2011. Electrolyte Imbalances. EMS World, 40(2), pp. 40-43.
Watanabe, A., Kato, N. & Kato, T., 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, Volume 42, pp. 279-285.
Wiegmann, D. & Shappell, S., 1993. Behavioral Effects of Tyrosine during Sustained Wakefulness, Florida: Naval Aerospace Medical Research Laboratory.
INGREDIENTS


Amino Acids

Electrolytes

Vitamins

Nutrients
A M Williamson & Feyer, A.-M., 2000. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occupational Environmental Medicine, Volume 57, pp. 649-655.
Adibi, S., 1970. Leucine absorption rate and net movements of sodium and water in human jejunum. Journal of Applied Physiology, 28(6), pp. 753-757.
Åkerstedt, T., 2009. Sleep Loss and Fatigue in Shift Work and Shift Work Disorder. National Institute of Health, 4(2), pp. 257-271.
Ando, S. et al., 2001. Enhancement of Learning Capacity andCholinergic Synaptic Function by Carnitinein Aging Rats. Journal of Neuroscience Research, Volume 66, pp. 266-271.
Banderet, L. & Lieberman, H., 1988. Treatment with Tyrosine, a neurotransmitter precursor, reduces environmental stress in humans, Massachusetts: US Army Research Institute of Environmental Medicine.
Blomstran, E., 2006. A Role for Branched-Chain Amino Acids in Reducing Central Fatigue. The Journal of Nutrition, Volume 136, pp. 544-547.
Choi, S., DiSilvio, B., Fernstrom, M. & Fernstrom, J., 2013. Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. Amino Acids, Volume 45, pp. 1133-1142.
Cian, C. et al., 1999. Influences of variations in body hydration on cognitive function: Effect of hyperhydration, heat stress, and exercise-induced dehydration. Journal of Psychophysiology, 14(1), pp. 29-36.
Deijen, J. et al., 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin, 48(2), pp. 203-209.
Fernstrom, J. D., 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Volume 45.
House of Representatives, 2000. Beyond the Midnight Oil, Canberra: Commonwealth of Australia.
Kennedy, D. et al., 2010. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, Volume 211, pp. 55-68.
Lanni, C., Lenzken, S. & Pascale, A., 2008. Cognition enhancers between treating and doping the mind. Pharmacological Research, Volume 57, p. 196–213.
Mahoney, C. et al., 2007. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiology & Behavior, Volume 92, pp. 575-582.
Papadelis, C. et al., 2003. Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain and Cognition, Volume 51, pp. 143-154.
Pasupathy, K. & Barker, L., 2011. Impact of fatigue on performance in registered nurses: data mining and implications for practice., s.l.: J Healthcare Quality.
Ricci, A. J., 2007. Fatigue in the U.S. Workforce: Prevalence and Implications for Lost Productive Work Time. JOEM, 49(1), pp. 1-9.
Seifert,, J., Harmon,, J. & DeClercq, P., 2006. Protein Added to a Sports Drink Improves Fluid Retention. International Journal of Sport Nutrition and Exercise Metabolism, Volume 16, pp. 420-429.
Smeland, O., Meisingset, T., Borges, K. & Sonnewald, U., 2012. Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61(1), pp. 100-107.
Tanaka, M., Mizuno, K. & Nozaki, S., 2007. Mental fatigue-induced decrease in levels of several plasma amino acids. Journal of Neural Transmission, Volume 114, pp. 555-561.
Vroman, R., 2011. Electrolyte Imbalances. EMS World, 40(2), pp. 40-43.
Watanabe, A., Kato, N. & Kato, T., 2002. Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience Research, Volume 42, pp. 279-285.
Wiegmann, D. & Shappell, S., 1993. Behavioral Effects of Tyrosine during Sustained Wakefulness, Florida: Naval Aerospace Medical Research Laboratory.